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The "gut-liver axis" is a critical pathway in the body

Endometriotic implants secrete estradiol (E2) as well as prostaglandin E2 (PGE2), agents that attract macrophages (monocyte chemotactic protein 1[MCP-1]), neurotrophic peptides (nerve growth factor [NGF]), enzymes for tissue remodeling (matrix metalloproteinases [MMPs]) and tissue inhibitors of MMPs (TIMPs), and proangiogenic substances such as vascular endothelial growth factor (VEGF) and interleukin-8 (6)

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People with diabetes generally have higher baseline risk of urinary tract infections due to impaired immune function and elevated blood glucose, regardless of medication type

Also based on their multiple nonglycemic effects, SGLT2is have therefore been suggested as the best glucose-lowering drug for managing patients with T2DM with heart failure (52)

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