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22 December 2025

Insulin is responsible for removing sugar from the bloodstream and transporting it into the bodys cells, where it can be utilized for energy or stored for later use

These include regulating the hosts immune system (triggering T cell differentiation), activating antigen-presenting cells (APCs) through an effect on Toll-like receptors (TLRs) or NOD-like receptors (NLRs), promoting the citrullination of peptides by enzymatic action, antigenic mimicry, and increasing the intestinal mucosal permeability (Horta-Baas et al., 2017

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Moreover, the significant implications of NRF2 hyperactivation, KEAP1 mutations, and BACH1 stabilization in cancer initiation, progression, and therapy resistance highlight the promising prospects of targeting the NRF2BACH1 signaling axis for therapeutic interventions in cancer management