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A role for EPAC-RAP1 signaling in suppressing mitochondrial ROS production in the heart has also been documented [5], supporting a role for EPAC-RAP1 signaling in mitochondrial ROS homeostasis in melanoma

For instance, dimerization of GluK2/K5 heterodimers (K D = 77 nM) occurs much more robustly and favorably compared to GluK2 homodimers (K D = 350 nM), contributing to the greater abundance of GluK2/K5 heterotetramers in the brain when compared to GluK2 homotetramers (Zhao et al., 2017)

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Most involve a relatively small number of subjects, and few of the research teams seem to have actually published papers describing their methods and data

The need to incorporate aged animals into the preclinical modeling of neurological conditions

Xiong Y, Yang Y, Yang J, Chai H, Li Y, Yang J, et al