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Who should not take GLP-1 medications

The abrasive action creates micro-inflammation that changes how the tissue handles absorption

Contrave (naltrexone/bupropion) Approved - An oral medication combining an opioid antagonist and an antidepressant

Recent animal studies suggest sublingual semaglutide may achieve significantly higher bioavailability than oral tablet forms, but human data remains limited

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Results with GLP-1s can take time, especially since doses are titrated gradually