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After 3-5 days, increase to 0.5 mg if tolerated

Molecular mediators governing iron-copper interactions

Biomaterials 221 , 119416 (2019)

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58 In the 3-month study with 20 women mentioned earlier, a significant skin-hydration increase (21%) was noted in the Pycnogenol group, particularly in women presenting with dry skin before Pycnogenol intake