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The findings were striking: for every 5 kg increase in weight or every inch added to waist circumference, the likelihood of RA onset climbs

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Regulatory agencies like the FDA require strong safety databases for drugs that will be prescribed to millions of people, and a trial of this size provides the statistical power needed to detect both efficacy signals and uncommon adverse events

Everything we know about its dosage comes from the Phase 2 trial published in the New England Journal of Medicine and the Phase 3 TRIUMPH-4 results released in late December of the previous year

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