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A patient who has built a high-protein, calorie-appropriate dietary pattern, is exercising at least 150 minutes per week of moderate-intensity activity per CDC recommendations [14], and has active behavioral health support may attempt a supervised stop
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and (iii) planned discontinuation and washout schedule
The combined interpretations from these studies support a model in which increased beta-cell GLP-1R signaling enhances alpha-cell GLP-1 production to amplify beta-cell function and insulin secretion through a local paracrine positive feedback loop of GLP-1 signaling ( Figure 5 )
Routine visits assist in tracking impacts and tweaking therapy as necessary
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