54 In contrast, IR and compensatory hyperinsulinemia cause abnormal activation of ovarian primordial follicles, increasing the sensitivity of pre-antral follicles to follicle-stimulating hormone (FSH), leading to excessive follicle recruitment and ultimately resulting in polycystic ovary-like changes
doi: 10.1016/j.ghir.2004.03.006 14 JaffeCATurgeonDKFribergRDWatkinsPBBarkanAL
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