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Over time, this leads to a natural reduction in calorie intake and, when combined with lifestyle changes, meaningful weight loss

Association of GLP-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases (JAMA Internal Medicine full text)

Temporary dose reduction during illness or significant life stress is reasonable, with resumption of escalation once circumstances normalize

A systematic review with meta-analysis

They are not a replacement for emergency care, crisis support, or treatment for severe psychiatric conditions, but they can be considered as an adjunct when someone is medically stable and looking for more complete brain and mood support

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