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Researchers have found that human proximal tubule epithelial cell lines exhibited distinct ultrastructural alterations indicative of pyroptosis when exposed to high glucose, and that the expression of TLR4, NLRP3, caspase-1, GSDMD-N, IL-1, and IL-18 are significantly upregulated (124)

Carnitine, which includes the compounds L-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine is a natural substance derived from an amino acid

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Its considered experimental, and its safety and efficacy profiles have not been firmly established through large-scale clinical trials

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