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Understanding that weight regain is a biological response rather than personal failure is essential for patients and clinicians

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Polycystic ovary syndrome creates insulin resistance that partially counteracts GLP-1 effects

Normal insulin function is closely related to mitochondrial function and dynamic balance, and insulin resistance directly leads to mitochondrial dysfunction

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Food and Drug Administration, (2020), "FDA requests the withdrawal of the weight-loss drug Belviq, Belviq XR (lorcaserin) from the market"