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Codevelopment of BI-770371 will continue for oncology indications, however, which was the initial target of the duos 1.4 billion (US$1.6 million) partnership in 2018

Poorly controlled hyperthyroidism poses greater risk

NRF2 and cancer NRF2 is frequently mutated in many types of cancers, with the mutations clustered around the DLG (43 %) and ETGE (57 %) motifs, which are the two critical KEAP1 interaction domains [95]

63 Typically, these effects are achieved by activating the nuclear erythroid 2-related factor 2 (Nrf2) neuroprotective and cytoprotective pathways

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