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Cryo-EM data processing RELION-3.1.2 were used for all data processing to yield the polished particle stack that was subjected into cryoSPARC v4.4.1 for 3D reconstitution 28,29

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Pyridoxal phosphate transfers amino groups, biotin transfers carbon dioxide (CO2) and carbamide coenzymes transfer alkyl groups

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Genomic instability and DNA damage response (DDR) Genomic instability, which involves damage to DNA and mutations, contributes to the acceleration of aging

In some cases, the cause may be a urinary tract infection (UTI)