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ER chaperone GRP78/BiP translocates to the nucleus under stress and acts as a transcriptional regulator

A structural model of the interaction suggests that the active molecule is a hydrolyzed form of PL (hPL) which forms a complex with GSH in the enzyme active site

Portable, pre-made

Activation of LDHA by oncogenic receptor tyrosine kinase FGFR1 promotes glycolysis and tumor growth by increasing the NAD + /NADH ratio, 368 while the aberration of NAD + /NADH due to reduced activity of mitochondrial complex I promotes the aggressiveness of human breast cancer cells

Source: Dietary Reference Intakes, Institute of Medicine (IoM)

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