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Biochim Biophys Acta 1841(2):227239 Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K et al (2018) Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis

The clinical trials tested maximum doses because that is what trials do

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The most commonly reported side effects in Phase 2 trials are gastrointestinal: nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation