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Oral administration at 100150mg to match subcutaneous bioavailability doubles the per-dose cost, which influences protocol design when budget constraints exist

They usually start with high doses and then lower them for maintenance

This result can be improved by using an aggressive laser along with a biostimulatory filler (like hyperdilute sculptra or radiesse), which will restore and repair the collagen in this area, as well as erase sun damage and deep wrinkles