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Current evidence suggests the answer is yes

220 This may be due to a marked increase in the activity of arginase induced by IL-4 and IL-13 and a marked increase in the downstream product putreamine in allergen-stimulated lungs

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FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells

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