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GLP-1 receptor agonists are a class of medications primarily used to manage type 2 diabetes mellitus and, more recently, obesity

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Calorie restriction appears to affect neurobiological pathways that control appetite, hunger, cravings and body weight, such that there is increased food intake and weight gain (Brown et al, 2022)

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Monotreme GLP-1 peptides are resistant to cleavage by human DPP-4 and human serum components but are cleaved in platypus and echidna sera, independently of DPP-4 activity Sequence alignments between human, platypus and echidna GLP-1 proteins (Fig