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The bottom line here is that the MCAS response to GLP-1 drugs appears to be highly individual
When considering adding a GLP-1 receptor agonist like Rybelsus, NICE guidance indicates these agents may be appropriate for people with type 2 diabetes who: Have a BMI of 35 kg/m or higher (adjusted for ethnicity) and specific psychological or medical problems associated with obesity, or Have a BMI lower than 35 kg/m and for whom insulin therapy would have significant occupational implications, or weight loss would benefit other significant obesity-related comorbidities GLP-1 therapy should only be continued if there is a beneficial metabolic response, defined as a reduction in HbA1c of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at six months
Ascorbyl Glucoside is water soluble and more gentle than many derivatives, because it converts to ascorbic acid directly into the skin
This is particularly interesting for individuals who experience depression alongside obesity or metabolic issues
Circulation (2004) 109:9625
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