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doi: 10.1016/j.pharmthera.2017.12.012

These chemicals are degraded by gut microbial enzymes (choline-TMA lyases) into trimethylamine (TMA), which subsequently enters the portal circulation and is oxidized in the liver by flavin-containing monooxygenases (FMOs) to produce TMAO (158)

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Currently available therapies consist of antifungal drugs belonging to azole and echinocandin families that interfere with different aspects of fungal metabolism

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