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Springer Nature Switzerland, Cham, pp 345357 Guo D, Liu Z, Zhou J et al (2024) Significance of programmed cell death pathways in neurodegenerative diseases

Bibcode:2019FrCh....7..852W

Using C2C12 mouse myoblasts, the study confirmed that the MGF E-domain peptide increases myoblast proliferation while inhibiting terminal differentiation and critically, that this effect was maintained in the presence of a neutralising anti-IGF-1R antibody directly establishing that MGF E-peptide signals via an IGF-1R-independent mechanism

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In human studies, curcumin supply resulted in a decrease in muscle damage and inflammatory biomarkers, with an approximate dosage of 1501500 mg/day administered pre-, post-, and during exercise, potentially enhancing athletic performance and muscle repair by mitigating exercise-induced muscle injury and modulating the inflammatory reaction (565, 566)