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Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD

47 , S29

More recent research suggests the story is more complicated

( Jiang TA

Originally identified in human plasma, GHK-Cu is naturally present in the body but declines significantly with age

Abbreviations MTHFR: Methylenetetrahydrofolate reductase GSTO-1: Glutathione S-transferase omega-1 ROS: Reactive oxygen species DNA: Deoxyribonucleic acid HHcy: Hyperhomocysteinemia Hcy: Homocysteine TOAST: Trial of ORG 10172 in Acute Stroke Treatment PCR: Polymerase chain reaction HWE: Hardy-Weinberg equilibrium