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Some individuals experience robust appetite suppression at the starting dose, while others require progression to 1.0 milligram or higher to achieve similar appetite control

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The study proved that combination therapy (60 mg duloxetine + 300 mg pregabalin) was not significantly more effective than high-dose monotherapy (either 120 mg duloxetine or 600 mg pregabalin) in reducing pain after 8 weeks of intensified treatment