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A GLP-1R agonist/GIPR antagonist peptide is theoretically possible but few full-length GIP-like antagonists were reported, 60 therefore it requires an array of attempts, at least an alanine-scan experiment of GIP with measuring of affinity

Particle sizes were optimized, with some as low as 1103 nm and a uniformity (PDI) as tight as 0.084 in certain batches

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