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Severe allergic reactions, such as itching or difficulty breathing, are rare but possible

Combining them is generally safe short-term, but studies show no added effectiveness over either drug alone

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For example, the recognized involvement of the HGF/c-Met system in the regulation of angiogenesis (see review- supports the potential utility of HGF/Met antagonists for the treatment of disorders in which control of tissue vascularization would be clinically beneficial