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The solvent Another possible cause of painful B12 injections is the solvent used to dissolve the B12 in the vial

Consider earlier administration (3+ hours before bed) to allow cortisol-modulating effects to establish before sleep pressure builds

The half-life means the drug accumulates to steady state over four to five weeks at a given dose

Stay in the Shade: If you're outdoors, keep your injections in a shaded, cool area rather than exposing them to direct sunlight

It is not intended as nutritional or medical advice for individual problems