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The original GIPR/GLP-1R agonist was modified with a C-18 acyl group to extend pharmacokinetics, and began Phase 1 clinical trials at Marcadia Biotech with Roche support (RG7697) 41,42 , leading to subsequent Phase 2 studies that were funded by Novo Nordisk (NNC00902746) 43

Samples treated with MTC, on the other hand, show extensive lipoperoxidative damage, as shown by the very high cytoplasmic MDA concentration (Figure 4a, bar to the left)

doi: 10.1038/nrn3275 201 SundalC.BakerM.KarrenbauerV.GustavsenM.BedriS.GlaserA.et al

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