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Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the GLP-1 receptor gene, the direct target of semaglutide), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (a transcription factor tied to glucose homeostasis and GLP-1 secretion) describe the terrain the molecule acts on

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Calcium and vitamin D are particularly important for bone health