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To bypass the skin barrier, several support techniques are being studied, such as: Microneedles: Tiny needles create microchannels in the skin, allowing drugs to enter the bloodstream directly

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The pH reduction is variable depending on several factors, but especially on the strain, and usually the reduction can range between 0.3 and 0.5 pH units (Table 1)

39 A prospective study of patients with moderate-to-severe plaque psoriasis showed a higher percentage of dermal T cells in psoriatic plaques when compared to control

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