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Khvatova EM, Rubanova NA, Prudchenko IA, Mikhailova II

The analysis also explores the therapeutic potential of targeting critical ferroptosis pathways, including dysregulated iron metabolism, impaired antioxidant defenses, and abnormal lipid peroxidation

Tyk2 knockout in NOD mice impaired the expression of T-BET, a transcription factor vital for cytotoxic T lymphocyte (CTL) development, in isolated CD8+ T cells stimulated with IL-12, as well as the cross-priming of autoreactive CTLs by resident dendritic cells in the pancreatic lymph node

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