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Rizzo M, Nikolic D, Patti AM, et al

Ozempic may cause bowel obstructions by slowing down how quickly food leaves the stomach

These results indicate that the increased amount of non-12-OH FXR-antagonistic BAs consequent to the decrease in CYP8B1 expression after T3 treatment potentiates GLP-1 production by deactivating the intestinal FXR, thereby improving glucose homeostasis via the augmentation of insulin secretion

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What did TRANSCEND-T2D-1 show