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Nevertheless, some of the phase 3 trials investigating the glucose-lowering effects of dulaglutide also report significant weight loss: The AWARD-11 trial reported 5.2% (11lb) weight loss from baseline at 52 weeks, at the highest dulaglutide dose of 4.5mg/weekly [18]

GLP-1 has a variety of physiological functions, which can regulate blood glucose level by promoting insulin secretion and synthesis, stimulating -cell proliferation and inducing islet regeneration, inhibiting -cell apoptosis and glucagon release, delaying gastric emptying and controlling appetite (Mller et al., 2019

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