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Individual ingredients may have modest supporting evidence, but their combined effect in marketed formulas remains largely unstudied in controlled trials

Appl Biol Chem 63:19 Park B et al (2019) Polygonum cuspidatum stem extract (PSE) ameliorates dry eye disease by inhibiting inflammation and apoptosis

Over the next few weeks, this may present as improved mood and energy

doi: 10.1177/039463200601900408

In a trial in which patients with obesity were treated with or without liraglutide 1.2 mg after diet-induced body weight loss of 12%, smaller decreases in free leptin and higher levels of PYY 3-36 were observed with liraglutide vs