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While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers
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While this is generally well tolerated, the high thiol load in circulation during the IV infusion period has not been studied alongside bisphosphonate renal clearance
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A1AT also has an effect on B lymphocytes, reducing their proliferation and function, as demonstrated in murine models of autoimmune diseases mediated by autoantibodies, such as rheumatoid arthritis, indicating a possible exploitation of A1AT as a therapeutic agent in autoimmune diseases (59) As for the effect on T cells, also the effect of A1AT on B lymphocytes seems to be indirect, mediated by the alterations in the extracellular milieu ( Figure 2 )
