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The article separately notes that these agents may alter gallbladder function, which is part of why that history is called out on its own line

Ongoing care includes provider-supervised dose escalation, which is how these medications are meant to be managed

However, similar to Saikosaponin D, the effects of Saikosaponin A on the Treg response need to be further investigated

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Understanding whether these drugs are physically crossing into the brain or having an effect by some secondary mechanism is important because drugs that cross the blood-brain barrier can be more effective but also introduce safety risks, DiMarchi says

Its ability to neutralise free radicals has led to it often being referred to as the master antioxidant