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IM B12 injection is especially appropriate when oral supplementation has been inadequate, when absorption is compromised, or when neurological symptoms are present (Stabler, New England Journal of Medicine , 2013)

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Solutions include diluting shots with additional 30-90 units bacteriostatic water to reduce irritation or mixing with BPC-157 in blends, which reportedly reduces injection pain significantly

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A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney disease

The safety profile remains favorable compared to many weight loss interventions, with most patients able to continue treatment successfully