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The use of food supplements , even natural ones, can help support the liver in certain cases, but should never replace medical treatment

reuteri as well as a tryptophan-rich diet to reprogram intraepithelial CD4 + T cells into immunomodulatory T cells (120)

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Similarly, metabolic abnormalities in PAECs, such as mitochondrial dysfunction and increased ROS production, promote endothelial inflammation and macrophage polarization through the release of metabolites like mtDNA and lactate (Geng et al., 2025

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