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PLoS One 2021;16:e0247307.ArticlePubMedPMC 4

Its the triple action that distinguishes it, because most existing medications attack one or two pathways

The FDA approved saxagliptin, linagliptin, and alogliptin, and the European Union and Japan approved vildagliptin, anagliptin, teneligliptin, trelagliptin, and omarigliptin

Gandhi cautions

While these medications are effective in the management of DMT2 and obesity, delayed gastric emptying can cause concerns for sedation and general anesthesia providers

Some GLP1 receptor agonists are approved for weight management in individuals without diabetes, but clinicians should weigh benefits, risks, and access considerations for each patient