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D., et al., PRX004 in Variant Amyloid Transthyretin (ATTRv) Amyloidosis: Results of a Phase 1, OpenLabel, DoseEscalation Study, Amyloid 32, no

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Insufficient levels of these vitamins hinder the efficient conversion of HCY to methionine, thereby disrupting the methylation cycle and diminishing the cells methylation capacity

Additionally, use of proton pump inhibitors (PPIs) and diuretics (or "water pills") such as furosemide and hydrochlorothiazide can lead to magnesium deficiency over time

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