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Safety, efficacy, and feasibility of intranasal insulin for the treatment of mild cognitive impairment and Alzheimer disease Dementia: A randomized clinical trial

For example, wild-type p53 protein induces IGFBP-3 expression, represses the transcription of IGF-II, and suppresses IGF-1R expression (96101)

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Oxidative stress is involved in a variety of neurodegenerative diseases, such as Alzheimers disease (AD), Huntingtons, and Parkinsons diseases [107,108,109], and neurodevelopmental disorders, including ASD [28, 110, 111]