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How Semaglutide Causes Side Effects (Briefly) Semaglutide mimics a gut hormone called glucagon-like peptide-1 (GLP-1)

The excessive ROS production during reperfusion can lead to the opening of the mitochondrial permeability transition pore (mPTP), causing mitochondrial swelling, loss of membrane potential, and cell death [2]

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These work by preventing the breakdown of GLP-1 the same hormone that Wegovy and similar drugs mimic to stimulate weight loss

Understanding GLP-1 & GIP: The Hormonal Messengers of Metabolism The human bodys metabolism is intricately regulated by various hormones, with incretins playing a crucial role