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Safety Considerations and Bottom Line Oral glutathione supplements are generally recognized as safe but ineffective for systemic antioxidant benefit due to low absorption

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Moreover, ex vivo studies show that PYC acts synergistically with lutein to reduce oxidative stress in porcine retinal homogenates (Nakanishi-Ueda et al., 2006)

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This means people with diabetes or those using insulin may need closer monitoring and possible dose adjustments