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Cellular senescence links aging and diabetes in cardiovascular disease

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Renal tissues from mice with CaOx crystal kidney injury and from negative control mice were collected for untargeted metabolomics

The downstream effects include activation of hormone-sensitive lipase in adipose tissue (which breaks down stored triglycerides into free fatty acids), increased protein synthesis in skeletal muscle, enhanced cellular repair and turnover, elevated IGF-1 production from the liver, and improved lipid metabolism including reduced triglycerides