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It was then accidently discovered, in a patient using cyclosporine, that psoriasis had a strong immunological component

Berberine is an alkaloid found in the roots, bark, and other structures of many plants, including the Oregon grape ( Mahonia aquifolium ), goldenseal ( Hydrastis canadensis ), Indian barberry ( Berberis aristata ), and European barberry ( Berberis vulgaris )