As protein-based biologics, they are extremely sensitive to temperature deviations: Too Cold (below +2 C): Freezing causes proteins in GLP-1 drugs to denature, making the batch unusable and resulting in immediate financial loss
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At standard dosestypically 0.5 to 1 milligram per kilogram of body weight per dayside effects can include dry skin and lips, hair thinning, joint pain, and increased sensitivity to the sun
In particular, curcumin (a polyphenol found in turmeric) and anthocyanin (found in blackcurrants) are thought to have effects on GLP-1 levels at least in rats [7]
Am J Cardiol 2014;114:384-8.ArticlePubMed 123
Pharmacokinetics and pharmacodynamics of a polyethylene glycol (PEG)-conjugated GLP-receptor agonist once weekly in Chinese patients with type 2 diabetes
