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When VDR was deleted specifically in the intestine (VDR int- ) of mice, the intestinal Ca 2+ absorption was decreased, the bone mineralization is inhibited and bone fractures were increased[10]

Beyond the SMAD pathway, various non-SMAD pathways, such as MAPK, c-Src, m-TOR, RhoA, RAS, PI3K/Akt, and protein phosphatase 2A/p70s6K are also regulated by TGF-

Interestingly, liver total lipid ( P = 0004), TAG ( P = 0000) concentration and liver weight (HSI, P = 0037) in the HF/H-LC group were lower than those in the HF group (Fig

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