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Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) ( via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)

Invest Ophthalmol Vis Sci 54(12):73957401 Das S et al (2018) Identification of a novel gene in ROD9 island of Salmonella enteritidis involved in the alteration of virulence-associated genes expression

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