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A meta-analysis of 21 clinical studies showed a weighted mean difference in body weight of 2.9 kg (95% confidence interval [CI] 3.6 to 2.2) with the maximum dose of each one of the GLP-1RAs [43]

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Semaglutide has excellent research backing as a GLP-1 medication, while tirzepatide is a newer drug thats thought to be more effective

Absorption is greater in the fasting state and reduced by factors such as certain foods, malabsorption, or concurrent use of agents like aluminum hydroxide, proton pump inhibitors, and calcium or iron supplements (Antonini et al

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