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The incidence of diabetic nephropathy is increasing concomitantly with the global surge in cases of diabetes mellitus [194]

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2c and Supplementary Table 2)

Despite promising preclinical data, targeting lipid peroxidation in clinical trials has not been successful [90], indicating that additional research exploring BBB penetrance of potential therapeutics and a better understanding of how lipid peroxides work in the temporal/biological context of TBI will be necessary before these metabolites can be harnessed for clinical benefit

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