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Vitamin B12 is sometimes added to support nerve health, which is important because people with diabetes have a higher risk of nerve damage

Although a few studies have been conducted in humans, the results are mixed and ultimately the drug is not approved by the US Food and Drug Administration (FDA)

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Results are typically slower and less noticeable compared to injections

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Selectivity was reported against COMT and against the SAM-dependent DNA and protein methyltransferases DNMT1 and PRMT3